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. 2019 Aug 14;10(8):621. doi: 10.1038/s41419-019-1848-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Summary of results from pressure–volume measurements in mouse hearts collected using the Scisense ADVantage^TM Admittance PV loop system, analysed with PowerLab software and statistical significance determined using students t test in Excel and Prism. Data represents mean and standard error (±) from six mice within each group (11 months old). *p ≤ 0.05. ESPVR = end systolic pressure–volume relationship; Ea arterial elastance; PRSW preload recruitable stroke work; PVA pressure–volume area; dV/dt_Max maximum conductance velocity; Ves end systolic volume; HW heart weight; HW:BW ratio heart weight:body weight ratio. b Echocardiography data showing parameters that are altered in Brn-3b KO mouse hearts when compared with age-matched WT control hearts. Data represent mean and standard error of multiple hearts (n ≥ 5)