Table 3.
Enriched gene pathways in memory-precursor CD8+ T cells
| Pathway | P-value | z score | Ratio | Major contributing genes |
|---|---|---|---|---|
| Oxidative phosphorylation | 1.00E-36 | 4.667 | 0.346 | NDUFB9, COX7B, MT-ND5, UQCR10, ATP5PB |
| EIF2 signaling | 1.00E-32 | −4.146 | 0.202 | RPS26,RPL32, RPS27, EIF4A2, RPL35A, RPS5 |
| Mitochondrial dysfunction | 3.16E-31 | – | 0.23 | NDUFB9, COX7B, MT-ND5, UQCR10, ATP5PB |
| mTOR signaling | 2.51E-16 | 0.816 | 0.137 | RPS26, RPS27, FKBP1A, EIF4B, EIF4A2, RPS5 |
| Regulation of eIF4 and p70S6K signaling | 6.31E-15 | – | 0.149 | RPS29, RPS6, RPS26, RPS27, RPS18, PABPC1 |
| Sirtuin signaling pathway | 6.31E-15 | 0.654 | 0.106 | JUN, NDUFB9, MT-ND5, ATP5PB, PGAM1 |
| Regulation of Actin-based motility by Rho | 2.00E-13 | 4 | 0.198 | ARPC3, MYL12B, WIPF1, ARPC5L, RAC2, ACTR3 |
| Signaling by Rho Family GTPases | 5.01E-12 | 2.836 | 0.099 | JUN, WIPF1, ARPC5L, ARPC1B, FOS, ARPC5 |
| RhoGDI signaling | 7.94E-12 | −3.299 | 0.119 | ARPC3, MYL12B, MSN, ARPC5L, ARPC1B |
| Cdc42 signaling | 2.00E-11 | 2.13 | 0.14 | JUN, HLA-DPB1, ARPC3, MYL12B, WIPF1 |