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. 2019 Aug 14;9:11814. doi: 10.1038/s41598-019-48342-7

Figure 1.

Figure 1

NK46 inhibited LPS production in mouse gut microbiota and NF-κB activation in LPS-stimulated microglial BV-2 cells. (A) Effect on LPS production. (B) Effect on fecal bacteria growth. Fecal bacterial cells (1 × 105 colony forming unit [CFU]/mL) were anaerobically incubated in 10 mL of general anaerobic medium (GAM) broth with NK46 (black, vehicle alone; gray, 1 × 105 CFU; white, 1 × 106 CFU/mL) for 24 h. Number of fecal bacteria were counted in the GAM agar plate. (C) Effect on LPS-induced NF-κB activation in BV-2 cells. BV-2 cells (5 × 105 cells/mL) were incubated with LPS in the absence or presence of NK46 (1 × 105 CFU/mL). All data were expressed as mean ± SD (n = 4). *p < 0.05 vs. control group treated with vehicle alone.