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. 2019 Jul 25;38(16):e100836. doi: 10.15252/embj.2018100836

Figure 2. Multiple levels of circRNAs’ evolutionary conservation.

Figure 2

To determine the level of conservation of a circRNA between two or more organisms, we offer to ask several general questions: 1. Are circRNAs present in both organisms? 2. Is a circRNA produced from the same (homolog or orthologue) gene in both organisms? 3. Is a circRNA produced from the same exon(s)? 4. Are the potential features conserved? This would imply the potential presence of an RBP and microRNA‐binding sites, presence of IRES(s) and translational stop(s). 5. Is a potential 3D structure conserved? 6. If the circRNA is translated, is also the peptide sequence homolog?