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. 2012 Dec 11;19(2):98–108. doi: 10.1111/cns.12041

Figure 1.

Figure 1

PLGA–aspirin microspheres modestly repressed the Wnt signaling pathway through slight blockage the β‐catenin transactivation. (A) SEM micrographs of PLGA–aspirin, PLGA–TMZ, and PLGA–aspirin–TMZ microspheres. (B) Release profiles of aspirin and TMZ from the PLGA microspheres. (C) CTNNB1 and downstream targets expression were analyzed by quantity real‐time PCR after PLGA or PLGA–aspirin microsphere treatment. (D) β‐catenin and related targets protein expression were assessed by Western blot analysis, while GAPDH serves as an internal. (E, F) β‐catenin transcriptional activity and STAT3 luciferase activity were detected after PLGA and PLGA–aspirin microsphere treatment. All data represented mean ± SD of three individual fields from experiments performed in triplicate for each treatment. *P < 0.05 compared with control and PLGA groups.