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. 2019 Aug 8;11:213. doi: 10.3389/fnagi.2019.00213

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Copyright © 2019 Tudela, Muñoz-Moreno, Sala-Llonch, López-Gil and Soria.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Linear mixed effect (LME) model fit of the shape as function of age and group for the anterior DMN subnetwork. Each dot represents the shape of one animal at one time point. (B) Mean and 95% confidence interval showing the evolution with time of the shape for each group and time point for the anterior DMN subnetwork. **Indicates significant difference (p_FDR < 0.05) between groups or time points connected by the line under it. Blue for the WT group and red for the TgF344-AD group.