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. 2019 Aug 8;13:307. doi: 10.3389/fncel.2019.00307

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Copyright © 2019 Izzy, Liu, Fang, Lule, Wu, Chung, Sarro-Schwartz, Brown-Whalen, Perner, Hickman, Kaplan, Patsopoulos, El Khoury and Whalen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Microglial gene expression after CCI. (A,B) Venn diagrams showing the overlap between 2, 14, and 60 dpi, vs. sham of (A) up-regulated genes (adjusted p-value < 0.05) and (b) down-regulated genes (adjusted p-value < 0.05). (C–E) Volcano plot showing the microglia gene expression of (C) 2 dpi vs. sham, (D) 14 dpi vs. sham, and (E) 60 dpi vs. sham. On the x-axis are the log2-fold changes and the y-axis is the –log10(p-value). Genes in black: False discovery rate (FDR) ≥ 0.05, |log2(FC)| ≤ 2; genes in green: FDR ≥ 0.05, |log2(FC)| > 2; genes in blue: FDR < 0.05, |log2(FC)| ≤ 2; and genes in red: FDR < 0.05, |log2(FC)| > 2. Genes in red with FDR ≤ 0.05, |log2(FC)| > 3 are named.