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. 2019 Aug 8;13:307. doi: 10.3389/fncel.2019.00307

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Copyright © 2019 Izzy, Liu, Fang, Lule, Wu, Chung, Sarro-Schwartz, Brown-Whalen, Perner, Hickman, Kaplan, Patsopoulos, El Khoury and Whalen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Microglial genes with highest confidence in gene networks after TBI. (A) TNF, IL6, and Tlr2 are among the top most confident centers of microglial upregulated genes network at 14 dpi. (B) IL-1β and CD40 are among the top 10 upregulated genes with the highest confidence in microglial gene networks at 60 dpi. The edge thickness indicates the strength of data support by STRING analysis, from thin, medium to thick corresponds to confident score 0.4, 0.7, and 0.9. The nodes are colored in alphabetical order of protein name, graphs in each node are known or predicted 3D structure.