Fig. 1.

Identification of candidate regulators of cognitive decline through genome-wide molecular profiling of human brain cells. The figure shows a schematic description of recent bioinformatic pipelines used to prioritize candidate genes with potential causative roles in cognitive decline, and of some of the top hits resulting from these approaches. Colored circles highlight genes identified with different strategies that are implicated in similar molecular pathways (pale blue, semaphorin/plexin signalling; red, insulin/IGF signalling; green, heat shock protein networks). See text for further details