Table 3.

Risk of all-cause of dementia associated with the dose–response of DMARD usage (n = 82,828)

Cohort	Case events	Model I		Model II
		aHR (95% CI)	p value	aHR (95% CI)	p value
Non-RA cohort	1258 (2.0)	Reference
RA without DMARD use (n = 6118)	139 (2.3)	0.82 (0.69–0.98)	0.032	Reference
DMARD cumulative DDDs (n = 14,589)
< 616 DDDs	52 (1.1)	0.59 (0.45–0.78)	0.032	0.68 (0.49–0.94)	0.021
616–1744 DDDs	43 (0.9)	0.57 (0.42–0.77)	< 0.001	0.63 (0.44–0.90)	0.012
> 1744 DDDs	11 (0.2)	0.18 (0.10–0.33)	< 0.001	0.20 (0.11–0.38)	< 0.001

Data are shown as n (%) for qualitative variables. The results were adjusted for age, gender, and all comorbidities

RA = rheumatoid arthritis; DMARD = disease-modifying anti-rheumatic drug; DDD = defined daily dose; aHR = adjusted hazard ratio; CI = confidence interval