Table 4.

The risk of all-cause of dementia between the non-RA and RA cohorts stratified by age and gender

Characteristic	Case events	cHR (95% CI)	p value	aHR (95% CI)	p value
Gender
Female
Non-RA cohort	771 (1.7)	Reference		Reference
Non-DMARD user	82 (2.2)	1.51 (1.21–1.90)	< 0.001	0.82 (0.65–1.03)	0.081
DMARD user	74 (0.7)	0.38 (0.30–0.49)	< 0.001	0.54 (0.43–0.69)	< 0.001
Male
Non-RA cohort	487 (2.8)	Reference		Reference
Non-DMARD user	57 (2.3)	1.00 (0.76–1.32)	0.999	0.71 (0.54–0.95)	0.016
DMARD user	32 (1.0)	0.35 (0.24–0.49)	< 0.001	0.47 (0.33–0.68)	< 0.001
Age (years)
< 65
Non-RA cohort	232 (0.5)	Reference		Reference
Non-DMARD user	31 (0.8)	1.90 (1.31–2.77)	0.001	1.27 (0.87–1.85)	0.222
DMARD user	26 (0.2)	0.46 (0.31–0.69)	< 0.001	0.53 (0.35–0.80)	0.002
≥ 65
Non-RA cohort	1026 (7.2)	Reference		Reference
Non-DMARD user	108 (4.8)	0.82 (0.67–1.00)	0.052	0.69 (0.57–0.85)	< 0.001
DMARD user	80 (3.0)	0.41 (0.33–0.52)	< 0.001	0.51 (0.41–0.64)	< 0.001

Data are shown as n (%) for qualitative variables. The results were adjusted for age, gender, and all comorbidities

RA = rheumatoid arthritis; DMARD = disease-modifying anti-rheumatic drug; cHR = crude hazard ratio; aHR = adjusted hazard ratio; CI = confidence interval