Fig. 1.

FMD treatment retains motor function in PD mice without an overall reduction in calorie intake. (a) Timeline for the experimental procedure, including FMD, MPTP administration, and tissue collection. (b) Body weight changes. NS-AL group (n = 17), NS-FMD group (n = 15), MPTP-AL group (n = 18), MPTP-FMD group (n = 16). (c) Average food intake in per cycle, n = 13 mice per group. (d) Pole descent test: time taken represents degree of bradykinesia, F_3,59 = 48.325, p < 0.001. NS-AL group (n = 16), NS-FMD group (n = 15), MPTP-AL group (n = 18), MPTP-FMD group (n = 14). (e) Traction test: suspension reflex score for evaluation of muscle strength and equilibrium, F_3,62 = 33.929, p < 0.001. NS-AL group (n = 17), NS-FMD group (n = 15), MPTP-AL group (n = 18), MPTP-FMD group (n = 16). Statistical comparison by one-way ANOVA with post hoc comparisons of LSD; data represent the means ± SEM; ***p < 0.001