Table 1.
Metabolites significantly different between NS-AL mice, NS-FMD mice, MPTP-AL mice, and MPTP-FMD mice
| Metabolite name | Group area | p value | ||||
|---|---|---|---|---|---|---|
| NS-AL | NS-FMD | MPTP-AL | MPTP-FMD | NA vs MA | MA vs MF | |
| Nabilone | 235,989.146 | 294,765.137 | 1,257,579.028 | 215,382.279 | 0.000 | 0.000 |
| (+/-)-C75 | 680,293.806 | 517,123.521 | 1,210,846.783 | 544,569.239 | 0.023 | 0.000 |
| DHODA | 327,663.535 | 532,275.022 | 877,131.152 | 462,184.206 | 0.002 | 0.019 |
| HMD | 53,962.615 | 62,167.321 | 86,775.525 | 68,637.613 | 0.000 | 0.012 |
| DD | 100,272.217 | 148,574.161 | 484,863.732 | 153,603.871 | 0.017 | 0.009 |
| DMTONP | 125,426.346 | 116,370.042 | 223,137.245 | 126,821.000 | 0.038 | 0.007 |
| DOYOHPG | 25,211.672 | 12,475.515 | 45,159.253 | 20,469.442 | 0.013 | 0.000 |
| CB | 145,833.080 | 154,221.161 | 271,099.846 | 159,665.778 | 0.013 | 0.021 |
| Amiloride | 238,887.600 | 307,173.260 | 354,206.744 | 263,971.306 | 0.038 | 0.041 |
| Isotretinoin | 59,463.054 | 60,938.786 | 127,714.747 | 47,842.018 | 0.023 | 0.004 |
| OA | 1,943,202.465 | 1,027,283.695 | 4,580,878.126 | 671,457.972 | 0.020 | 0.000 |
| DA | 480,374.351 | 431,783.114 | 1,074,167.337 | 459,382.734 | 0.028 | 0.010 |
| Acetylshikonin | 19,175.807 | 14,936.875 | 130,986.051 | 54,539.617 | 0.000 | 0.000 |
| APM | 4,765,796.770 | 4,623,011.580 | 6,367,601.718 | 4,309,795.694 | 0.022 | 0.030 |
| Asn-pro | 471,638.531 | 255,744.091 | 1,683,488.277 | 204,730.296 | 0.029 | 0.000 |
| Butopyronoxyl | 398,110.205 | 430,235.694 | 246,370.465 | 379,338.191 | 0.009 | 0.002 |
| Azepan-2-one | 603,840.601 | 1,052,156.329 | 1,358,330.455 | 655,218.171 | 0.019 | 0.031 |
| Capuride | 631,293.088 | 444,456.466 | 1,513,175.750 | 597,204.371 | 0.014 | 0.012 |
| D-alanyl-D-alanine | 87,004.215 | 70,330.655 | 162,157.917 | 41,723.162 | 0.040 | 0.000 |
| Dicyclomine | 28,386.440 | 38,897.550 | 95,167.637 | 59,070.153 | 0.001 | 0.048 |
| Dimetofrine | 1,101,806.320 | 1,218,218.937 | 1,552,813.269 | 1,009,942.181 | 0.000 | 0.002 |
| DL-glutamine | 963,370.395 | 852,459.578 | 1,573,320.886 | 830,824.823 | 0.041 | 0.038 |
| Ecgonine | 1,050,773.518 | 1,155,764.435 | 1,584,894.876 | 1,320,973.812 | 0.003 | 0.022 |
| Fluoxymesterone | 169,478.346 | 126,366.586 | 285,577.725 | 69,871.843 | 0.021 | 0.000 |
| Gaboxadol | 838,644.723 | 495,145.180 | 3,587,141.441 | 431,456.273 | 0.001 | 0.000 |
| g-Butyrobetaine | 331,073.074 | 371,449.711 | 143,574.251 | 264,044.660 | 0.003 | 0.026 |
| Imazapyr | 356,735.134 | 292,676.658 | 535,542.221 | 343,288.343 | 0.048 | 0.016 |
| Kanosamine | 279,368.544 | 291,453.904 | 674,447.531 | 258,624.473 | 0.025 | 0.006 |
| L-alanyl-L-proline | 455,340.888 | 598,910.371 | 2,976,694.869 | 368,637.531 | 0.000 | 0.000 |
| L-alanyl-L-proline | 89,073.879 | 53,265.814 | 205,415.316 | 82,780.940 | 0.044 | 0.001 |
| CHL | 55,659.106 | 57,587.451 | 92,877.573 | 39,122.642 | 0.023 | 0.000 |
| TBL | 289,761.462 | 323,549.493 | 102,525.415 | 423,331.316 | 0.003 | 0.000 |
| DT | 434,040.911 | 426,685.688 | 782,288.765 | 429,381.221 | 0.041 | 0.007 |
| AG | 563,300.118 | 484,839.231 | 1,438,941.847 | 320,271.507 | 0.006 | 0.000 |
| N-acetyl-L-histidine | 472,083.471 | 318,819.989 | 1,027,780.111 | 430,988.660 | 0.042 | 0.026 |
| OM | 614,273.359 | 577,943.473 | 449,549.780 | 663,925.220 | 0.012 | 0.044 |
| Oxaceprol | 252,224.047 | 290,325.254 | 535,997.134 | 293,632.530 | 0.001 | 0.001 |
| Oxaceprol | 530,732.549 | 306,802.171 | 849,670.647 | 398,505.474 | 0.023 | 0.000 |
| PE | 1,075,226.380 | 1,063,171.498 | 2,396,963.022 | 979,733.677 | 0.008 | 0.000 |
| Acetamide | 49,648.898 | 47,154.069 | 125,139.271 | 42,930.012 | 0.005 | 0.004 |
| QV1MVO1R | 508,324.698 | 648,284.260 | 833,894.039 | 582,818.321 | 0.000 | 0.004 |
| Ricinoleic acid | 1,332,037.285 | 1,903,531.420 | 2,847,023.712 | 1,188,492.912 | 0.002 | 0.000 |
| Ricinoleic acid | 246,590.512 | 241,407.359 | 572,062.309 | 267,292.771 | 0.012 | 0.023 |
| trans-Anethole | 58,787.265 | 66,823.862 | 206,866.881 | 135,176.683 | 0.000 | 0.020 |
| UNII:OUT5YHB7BO | 87,853.504 | 99,590.773 | 166,246.580 | 82,988.887 | 0.026 | 0.000 |
In all metabolites mentioned above, there is no significant difference of group area between NA group and NF group (p ≥ 0.05). Statistical comparison by one-way ANOVA with post hoc comparisons of LSD
NA = NS-AL group (n = 12); NF = NS-FMD group (n = 18); MA = MPTP-AL group (n = 14); MF = MPTP-FMD group (n = 16); DHODA = 5Z,11beta,13E,15S)-11,15-dihydroxy-N-(2-hydroxyethyl)-9-oxoprosta-5,13-dien-1-amide; HMD = 1-(4-hydroxy-3-methoxyphenyl)-3,5-diacetoxyoctane; DD = 1,1′-[1,12-dodecanediylbis(oxy)]dibenzene; DMTONP = 1,2-dideoxy-3-C-methyl-1-(2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydro-1-naphthalenyl)pentitol; DOYOHPG = 1-O-[{[(2E)-3,7-dimethyl-2,6-octadien-1-yl]oxy}(hydroxy)phosphoryl]-beta-D-glucopyranose