Table 3. Clinical Characteristics of Patients With and Without Sudden Cardiac Death End Points and Univariable Cox Proportional Hazards Regression Models.
| Characteristic | No. (%) | Hazard Ratio (95% CI) | P Value | ||
|---|---|---|---|---|---|
| Whole Cohort (N = 1024) | Patients With SCD End Points (n = 89) | Patients Without SCD End Points (n = 938) | |||
| Age, median (IQR) | 11 (7-14) | 10 (6-13) | 11 (7-14) | 1.05 (1.00-1.11) | .06 |
| Male sex | 699 (68.3) | 65 (73) | 634 (67.8) | 0.73 (0.50-1.17) | .20 |
| NYHA class >1 | 223 (22.2) | 28 (31.8) | 195 (21.2) | 1.70 (1.08-2.65) | .02 |
| Family history | |||||
| SCD | 130 (12.8) | 12 (13.5) | 118 (12.7) | 1.01 (0.55-1.85) | .98 |
| HCM | 534 (53.1) | 42 (48.3) | 492 (53.5) | 0.83 (0.55-1.27) | .39 |
| Unexplained syncope | 102 (9.9) | 16 (18) | 86 (9.2) | 2.06 (1.20-3.54) | .009 |
| NSVT | 55 (6.4) | 12 (16.4) | 43 (5.5) | 1.93 (1.03-3.61) | .04 |
| MWT, mean (SD), mm | 17.1 (7.4) | 20 (7.5) | 16.9 (7.3) | 1.05 (1.02-1.07) | <.001 |
| z Score MWT, mean (SD) | 11.1 (7.1) | 15 (7.5) | 10.7 (7) | 1.05 (1.02-1.08) | <.001 |
| MWT ≥30 mm | 81 (7.9) | 25 (31.7) | 164 (20.7) | 2.35 (1.33-4.18) | .004 |
| LA diameter, mean (SD), mm | 33.4 (8.5) | 36.5 (9.3) | 33 (8.3) | 1.05 (1.02-1.08) | .001 |
| z Score LA diameter, mean (SD) | 1.9 (2.3) | 3.2 (2.6) | 1.8 (2.2) | 1.19 (1.08-1.30) | <.001 |
| LVOTg max, median (IQR), mm Hg | 9 (6-22) | 12 (6-36) | 9 (6-20) | 1.00 (0.99-1.01) | .83 |
| LVOT ≥30 mm Hg | 189 (18.4) | 25 (31.7) | 164 (20.7) | 1.48 (0.92-2.38) | .11 |
Abbreviations: HCM, hypertrophic cardiomyopathy; LA, left atrium; IQR, interquartile range; LVOTg max, maximal left-ventricular outflow tract gradient; MWT, maximal wall thickness; NSVT, nonsustained ventricular tachycardia; NYHA, New York Heart Association; SCD, sudden cardiac death.