TABLE 5.
Plasma Biomarker Levels in Patients with and without Postoperative Cognitive Dysfunction (POCD).
| Total | POCD | Non-POCD | P-value | |
| TNF-α (ng/L) | ||||
| D0 | 34.6 ± 6.9 | 36.5 ± 8.0 | 33.2 ± 5.6 | 0.023∗ |
| D1 | 47.0 ± 11.6 | 52.1 ± 11.9 | 43.5 ± 9.9 | 0.001∗∗ |
| D3 | 43.5 ± 12.2 | 47.9 ± 12.6 | 40.4 ± 11 | 0.001∗∗ |
| D7 | 33.5 ± 9.6 | 37.2 ± 11.5 | 30.9 ± 7 | 0.003∗∗ |
| CRP (ng/ml) | ||||
| D0 | 6.2 ± 12.6 | 7.4 ± 15.3 | 5.3 ± 10.4 | 0.411 |
| D1 | 58.9 ± 26.2 | 66.2 ± 29.1 | 53.7 ± 22.9 | 0.011∗∗ |
| D3 | 114.7 ± 38.5 | 134.6 ± 40.2 | 100.7 ± 30.6 | 0.000∗∗ |
| D7 | 39.8 ± 26.5 | 49.0 ± 31.8 | 33.28 ± 19.9 | 0.008∗∗ |
| S100β (ng/L) | ||||
| D0 | 303.4 ± 68.5 | 314.2 ± 68.6 | 295.2 ± 67.8 | 0.110 |
| D1 | 364.8.1 ± 64.6 | 377.0 ± 73.4 | 356.4 ± 56.7 | 0.088 |
| D3 | 335.1 ± 79.6 | 346.4 ± 95.2 | 327.3 ± 66.2 | 0.309 |
| D7 | 306.7 ± 75.7 | 329.0 ± 92.9 | 294.0 ± 54 | 0.436 |
Continuous variables are reported as mean ± SD, using the Student t-test or the Wilcoxon test appropriately. ∗p < 0.05; ∗∗p < 0.01; TNF-α, Tumor necrosis factor α; CRP, C reactive protein; S100β, S100 calcium binding protein β. D0, before surgery; D1, 1 day after surgery; D3, 3 days after surgery; D7, 7 days after surgery.