TABLE 1.
Receptor expression in human, mouse and rat pancreatic islets and beta cells of cytokines and chemokines detected in conditioned media from human myotubes.
| Protein | Gene | Uniprot identifier | Receptor | mRNA expression | |||||
| Beta cells | Islets | ||||||||
| Human | Mouse | Rat | Human | Mouse | Rat | ||||
| GRO α/β/γ | CXCL1/2/3 | P09341/P19875/P19876 | CCR-1 | − | − | − | − | ++ | − |
| CCR-5 | − | − | + | + | ++ | − | |||
| CXCR-1 | ++ | − | No data | No data | − | + | |||
| CXCR-2 | ++ | − | + | − | − | − | |||
| CXCR-3 | +++ | − | ++ | ++ | + | + | |||
| IFN-γ | IFN-G | P01579 | INFGR-1 | ++ | +++ | +++ | ++ | +++ | ++ |
| INFGR-2 | ++ | +++ | + | ++ | +++ | ++ | |||
| IL-1β | IL-1B | P01584 | IL1R-1 | +++ | ++ | +++ | +++ | +++ | + |
| IL1R-2 | + | +++ | ++ | ++ | ++ | ++ | |||
| IL-2 | IL-2 | P60568 | IL2R-α | − | − | + | + | + | − |
| IL2R-β | − | + | − | ++ | ++ | + | |||
| IL-6 | IL-6 | P05231 | IL6R | + | ++ | +++ | +++ | − | ++ |
| IL-7 | IL-7 | P13232 | IL2R-γ | ++ | − | +++ | − | ++ | + |
| IL7R | ++ | No data | ++ | + | + | No data | |||
| IL-8 | CXCL8 | P10145 | CXCR-1 | ++ | − | No data | No data | − | + |
| CXCR-2 | ++ | − | + | − | − | − | |||
| DARC | ++ | No data | ++ | ++ | − | No data | |||
| IL-10 | IL-10 | P02778 | IL10R-α | ++ | + | − | − | ++ | − |
| IL10R-β | +++ | ++ | +++ | ++ | +++ | No data | |||
| IL-12 | IL-12A/B | P29459/P29460 | IL12R-β1 | − | No data | + | − | + | No data |
| IL12R-β2 | + | + | ++ | ++ | + | No data | |||
| LIF | LIF | P15018 | LIFR | − | + | + | ++ | ++ | + |
| M-CSF | CSF1 | P09603 | CSF1R | + | + | +++ | + | ++ | + |
| MCP-1 | CCL2 | P13500 | CCR-1 | − | − | − | − | ++ | − |
| CCR-2 | No data | − | ++ | + | No data | − | |||
| CCR-5 | − | − | + | + | ++ | − | |||
| MIF | MIF | P14174 | CXCR-2 | ++ | − | + | − | − | − |
| EGFR | + | +++ | +++ | ++ | +++ | +++ | |||
| RANTES | CCL5 | P13501 | CCR-1 | − | − | − | − | ++ | − |
| CCR-2 | No data | − | ++ | + | No data | − | |||
| CCR-3 | + | + | − | − | − | + | |||
| CCR-4 | − | + | + | − | − | + | |||
| CCR-5 | − | − | + | + | ++ | − | |||
| GPR75 | No data | + | − | + | + | No data | |||
| VEGF-A | VEGFA | P15692 | VEGFR-1 | ++ | No data | +++ | + | +++ | No data |
| VEGFR-2 | + | ++ | +++ | + | ++ | ++ | |||
| G-CSF | P09919 | CSF3R | + | + | No data | + | ++ | No data | |
| IL-13 | P35225 | IL13RA1 | + | ++ | ++ | +++ | ++ | +++ | |
| TNF-α | P01375 | TNFRSF1A/TNFR1 | +++ | +++ | +++ | +++ | +++ | +++ | |
| TNFRSF1B/TNFBR | +++ | + | − | + | ++ | − | |||
| IL-4 | P05112 | IL4R | ++ | + | − | +++ | + | − | |
| IL13RA1 | + | ++ | ++ | +++ | ++ | +++ | |||
Specific receptor name for each cytokine and chemokine detected in human myotube conditioned media in Hartwig et al. (2014) and Mizgier et al. (2017) studies (see Supplementary Table 2) were identified browsing the UniProt and STRING protein databases. Receptor mRNA expression were obtained from the Beta Cell Gene Atlas (Smink et al., 2005). Low (+), moderate (++), enriched (+++) expression level; not expressed (−).