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. 2019 Aug 8;10:550. doi: 10.3389/fendo.2019.00550

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Copyright © 2019 Wang, Jin, Zhao and Ni.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of melatonin on glutamate-induced oxidation of HT22 cells. (A) Effect of melatonin on the activity of SOD in cells: F = 19.937, P < 0.001; control group vs. glutamate injury group: P < 0.001, glutamate injury group vs. melatonin pretreatment group: P = 0.034; (B) Effect of melatonin on the intracellular GSH concentration: F = 9.315, P < 0.001; control group vs. glutamate injury group: P = 0.011, glutamate injury group vs. melatonin pretreatment group: P = 0.044; (C) Effect of melatonin on the intracellular GSSG concentration: F = 5.921, P = 0.005; control group vs. glutamate injury group: P = 0.014, glutamate injury group vs. melatonin pretreatment group: P = 0.045; (D) Effects of melatonin on GSH/GSSG ratio in cells: F = 8.363, P = 0.001; control group vs. glutamate injury group: P = 0.011, glutamate injury group vs. melatonin pretreatment group: P = 0.039; *P < 0.05, **P < 0.01. ns, not significant (n = 6/group).