Table 1.

Metabolic consumption/production perditions S-GPR vs GPR

Metabolites’ uptake/secretion that have been wrongly predicted by GPR-based analyses and corrected when applying S-GPRs. In the first column are represented the metabolites. Column 2 and 3 show the significant metabolites’ uptake/secretion experimentally measured in Aldrin-exposed and non-exposed DU145 cells respectively. Here green and red represents either metabolite consumption or production respectively. The four last columns represent the four different methods used to integrate transcriptomic data into a GSMM reconstruction analysis. Here, cells highlighted in gray represents those cases in which GPR-based analyses provided a wrong prediction that was corrected when using S-GPR instead (the opposite case haven’t been observed in our case study)