Table 1.

Characteristics of included studies on association between frailty and clinical outcomes

Study	Study type	Location	Type of ACS	Frailty measure	Age	Sample Size (n)	No.of Males	Prevalence (frailty,%)	Prevalence (pre-frailty)	Follow-up (mo)
Ekerstad 2011	Prospective	Sweden	NSTEMI	CSHA-CFS	≥ 75	307	257	48.50%	N/A	1
Ekerstad 2014	Prospective	Sweden	NSTEMI	CSHA-CFS	≥ 75	307	257	48.50%	N/A	12
Graham 2013	Prospective	Canada	ACS	EFS	≥ 65	183	123	30.05%	35.50%	12
Sanchis 2014	Prospective	Spain	ACS	Green scores	≥ 65	342	196	48.00%	N/A	Mean 25 (31–72)
Sanchis 2018	Prospective	Spain	ACS	Green scores	≥ 65	342	196	48.00%	N/A	Mean 56.4
Kang 2015	Prospective	China	ACS	CSHA-CFS	≥ 65	352	203	43.20%	N/A	6.3
Sujino 2015	Retrospective	Japan	STEMI	CSHA-CFS	≥ 85	62	36	35.50%	N/A	in-hospital
White 2016	Prospective	Multicentre	UA/NSTEMI	Fried Frailty score	≥ 65	4996	2691	4.70%	23.00%	Mean  17.1 (10.4–24.4)
Alonso 2016 a	Prospective	Spain	type 1 MI	SHARE-FI	≥75	190	115	37.90%	28.40%	1
Alonso 2016 b	Prospective	Spain	type 1 MI	SHARE-FI	≥75	202	121	35.10%	36.60%	in-hospital
Alonso 2017	Prospective	Spain	type 1 MI	SHARE-FI	≥75	234	139	40.20%	28.2%	6
Alonso 2018	Prospective	Spain	type 1 MI	SHARE-FI	≥75	285	171	38.20%	29.80%	12
Kirill 2017	Prospective	Russia	ACS	Computer program of geriatric examination	elderly Senile	633	N/A	35.50%	N/A	12
Blanco 2017	Prospective	France	ACS	EFS	≥ 80	236	N/A	20.8%	28.8%	Mean 15.7
Alegre 2018	Prospective	Spain	NSTEMI	FRAIL scale	≥ 80	532	328	27.30%	38.50%	6

CSHA-CFS Canadian Study of Health and Aging Clinical Frailty Scale; EFS Edmonton Frail Scale; STEMI ST-segment elevation myocardial infarction; NSTEMI, non-ST-segment elevation myocardial infarction; ACS acute coronary syndrome; MI myocardial infarction; UA unstable angina; CSHA-CFS Canadian Study of Health and Aging Clinical Frailty Scale; SHARE-FI Survey of Health, Ageing and Retirement in Europe Frailty Index; N/A not available