Table 2.

Comparison of response between the early and late period response

Response	Early perioda (after 3 cycles)	Late periodb (after 6 cycles)	P value
CR	2 (2.0%)	5 (9.4%)
PR	35 (34.3%)	9 (17.0%)
SD	46 (45.1%)	11 (20.8%)
PD	19 (18.6%)	28 (52.8%)
RR (CR + PR)	37 (36.3%)	14 (26.4%)	0.028
DCR (CR + PR + SD)	83 (81.4%)	25 (47.2%)	0.492

CR complete response, PR partial response, SD stable disease, PD progressive disease, RR response rate, DCR disease control rate

^aOne patient was excluded because there was no sufficient data for evaluating response to treatment

^bThe late period response was evaluated in 53 patients