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. 2019 Aug 14;19:806. doi: 10.1186/s12885-019-6021-6

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© The Author(s). 2019

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Diagnostic and prognostic power of CASC9 and HOTAIR in different HNSCC tissue sets. (a) Diagnostic power was determined by ROC curve analysis for CASC9 in the TCGA data set, the BN set and the DUS set and demonstrated excellent tumor specificity of CASC9. The same analysis was performed for lncRNA HOTAIR (b). 95% confidence interval values are given in brackets. Prognostic power was determined by Kaplan-Meier analysis. Increased expression of CASC9 and HOTAIR had significant impact on overall survival of all patients from the TCGA set (c, d) and also among the HPV-negative patients (e, f)