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. 2019 Aug 15;19:721. doi: 10.1186/s12879-019-4355-y

Table 3.

Schedule of the CROPrEP project

Procedures Screening/Enrollment FU
1 m ± 7dd
FU
3 m ± 7d
FU
6 m ± 7d
FU
9 m ± 7d
FU
12 m ± 7d
Informed consent ×
Self-administrated questionnaire × × × × × ×
Interviews
 Relevant medical history ×
 Current/concomitant medication × × × × × ×
 Adverse events or side effects × × × × ×
Medication return and allocation × × × × × ×
HIV/STIs testing
 HIV screening × × × × × ×
 HIV Western Blota × × × × × ×
 HIV RNA Pooling PCRb × × × × × ×
 HIV resistance testingc
 HIV-1 viral loadc
 Syphilis × × × × × ×
 HSV-2 × × × × × ×
Safety assessment
 Routine blood tests × × × × × ×
 Routine urine tests × × × × × ×
 Liver functions tests × × × × × ×
 Renal functions tests × × × × × ×
 Blood glucose and lipids × × × × × ×
 Bone mineral density × × ×
 Hepatitis B virus × × ×
Adherence lab assessment
 Blood drug level testing × × × × ×

Abbreviations: FU Follow-up, m Month(s), d Day, HSV-2 Herpes simplex virus 2

aAnyone who screens positive for HIV will have the results confirmed by western blotting

bAnyone who screens negative for HIV will have the results confirmed by HIV RNA pooling PCR test

cAnyone who tests positive for HIV will have their samples further tested for HIV resistance and viral load

dVisit window, 7 days