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. 2019 Aug 15;20:169. doi: 10.1186/s13059-019-1770-8

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© The Author(s) 2019

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — The tools perform similarly with data from different real E&R studies. We performed a PCA with the normalized test statistics for tools supporting (left panel) and not supporting replicates (right panel). Data are from E&R studies in D. simulans [7], C. elegans [33], and yeast [9]