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. 2019 Aug 14;7:217. doi: 10.1186/s40425-019-0700-3

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Identification of the T_AI cell subset in humans. (a) Heatmap of CD8⁺ T-cell phenotypes (pre-gated on CD45⁺ CD3⁺ CD4⁻ cells) in tumors of 5 human colorectal cancer (MMRd) patients. Dendrogram above shows the hierarchical similarity between the identified clusters. Right panel shows the frequency of CD8⁺ LAG3⁺ ICOS⁺ cells (cluster 8) among total CD8⁺ T cells across the 5 patients. (b) Gating strategy to identify the CD4⁺ CD69⁺ PD1⁺ CD39⁺ ICOS⁺ population in human colorectal cancer. The abundance proportional to circle area is shown