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. 2019 Aug 15;20:167. doi: 10.1186/s13059-019-1783-3

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Target availability by Cas enzyme. a PAM frequencies in the human reference genome hg19, colored by the size of the PAM site (number of non-“N” nucleotides in motif). b In this faceted density plot, the height of the colored portion indicates the proportion of genes where the specified percentage (on the x-axis) of the 1000 Genomes cohort is putatively targetable