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. 2019 Aug 15;20:167. doi: 10.1186/s13059-019-1783-3

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — sgRNA pair optimization for coverage of groups. a Variant pairs in NEFL and the flanking 5 kb that are shared by at least 10% of the 1KGP cohort. These are pairs of variants, not pairs of sgRNAs, so reflect potential dual-guide editing sites prior to designing or filtering sgRNAs. Ten percent was chosen for visualization purposes. b Five variant pairs identified by AlleleAnalyzer to achieve greatest possible coverage of the 1KGP cohort. c Coverage of the 1KGP cohort with the AlleleAnalyzer set of five pairs at various minimum predicted specificity score thresholds. d Coverage of each super population in the 1KGP cohort with the AlleleAnalyzer set of five pairs at various minimum predicted specificity score thresholds. e Top 5 shared variant pairs in the 1KGP cohort. f Coverage of the 1KGP cohort with the “top 5” set of pairs at various minimum predicted specificity score thresholds. g Coverage of each super population in the 1KGP cohort with the “top 5” set of pairs at various minimum predicted specificity score thresholds