Table 4.
ARBs inhibit tumorigenesis in cell and animal models.
| Drug name | Effect in tumor models or cell lines | Tumor types and references |
|---|---|---|
| Candesartan | Inhibition of growth and proliferation | Gastric cancer cells (121), lung cancer cells (122) |
| Reduced angiogenesis | Renal cancer (123), ovarian cancer (68), breast cancer (124) | |
| Reduced metastases | Renal cancer (123) | |
| Prolonged survival of tumor-bearing animals | Peritoneal carcinomatosis (121) | |
| Irbesartan | Reduced growth | Colorectal cancer liver metastases (112), esophageal squamous cell carcinoma cells (114) |
| Losartan | Reduced growth | Breast cancer (70), esophageal squamous cell carcinoma cells (114) |
| Increased proliferation | Melanoma cells (125) | |
| Reduced invasion | Breast cancer (70) | |
| Reduced angiogenesis | Pancreatic cancer (126) | |
| Olmesartan | Reduced invasion | Gastric cancer cells (61) |
| Telmisartan | Inhibition of growth and proliferation | Prostate cancer cells (127), uterine leiomyoma cells (128), lung cancer cells (129) |