Table 1.
Demographics and Cognitive Information
|
Characteristics |
aMCI/eAD,
n
= 12 |
Control,
n
= 12 |
P
Value* |
| Sex, male/female | 3/9 | 3/9 | |
| Age, y† | 71.92 ± 5.87 | 72.66 ± 6.43 | 0.98 |
| Education, y† | 16.12 ± 2.33 | 16.83 ± 1.64 | 0.59 |
| Race, n | |||
| African American | 1 | 1 | |
| Caucasian/Hispanic | 9/2 | 11/0 | |
| Diabetes, n§ | 1 | 0 | |
| Hypertension, n§ | 4 | 3 | |
| IOP, mm Hg† | 16.08 ± 2.91 | 16.58 ± 2.19 | 0.59 |
| No. of eyes imaged† | 1.50 ± 0.52 (18 total) | 1.75 ± 0.45 (21 total) | 0.32 |
| Area of eye imaged, mm2† | 8.52 ± 4.96 | 12.09 ± 8.12 | 0.38 |
| Interval between cognitive and imaging visits, y† | 0.386 ± 0.261 | 0.269 ± 0.190 | 0.20 |
| MoCA, total = 30† | 22.08 ± 3.70 | 26.92 ± 2.15 | <0.001 |
| CDR†‡ | 0.54 ± 0.14 | 0 ± 0 | <0.001 |
| CS Imm, total = 25† | 9.75 ± 2.73 | 17.50 ± 2.39 | <0.001 |
| CS Del, total = 25† | 6.33 ± 5.58 | 16.50 ± 3.03 | <0.001 |
| RAVLT Del, total = 15† | 2.91 ± 4.01 | 10.75 ± 3.31 | <0.001 |
Statistically significant P values are bold. CS Imm, Craft Story immediate; CS Del, Craft Story delayed; RAVLT Del, Rey Auditory Verbal Learning Test delayed recall.
*
2-tailed P values from Mann-Whitney U test.
†
Data reported as mean ± standard deviation.
‡
CDR scores range from 0 (no dementia) to 0.5 (questionable) to 1.0 (mild).
§
Participants with uncontrolled diabetes or hypertension or with retinopathy related to medical disease were excluded.