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Systematic analysis of the impact of calpain cleavage–related mutation sites and proteins. (A) CCRM proteins were significantly enriched in cancer-related pathways. (B) CCRM sites were more conserved than other mutations. (C) CCRM sites showed a preference to be enriched in known functional domain regions. (D–E) Patients with at least six CCRM sites had significantly worse clinical prognostic in HNSC (D) and LIHC (E).
