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. 2019 Aug 8;6:114. doi: 10.3389/fcvm.2019.00114

Figure 4.

Figure 4

Illustrates the degree of platelet activation in response to stimulation by four different agonists. The activation can be measured as a change in the expression of the activation-dependent platelet surface markers: Bound-fibrinogen, CD63 and P-selectin. (A–C) The percentage of activated platelets in response to stimulation by an agonist; (D–F) The median fluorescence intensity (MFI) of the activated platelets following stimulation by an agonist. Platelet activation on day 1 of support with extracorporeal membrane oxygenation (ECMO) is compared with platelet activation measured on day 3 of ECMO support, n = 24. Patients weaned from ECMO support prior to day 3 were excluded from this analysis on the difference between day 1 and 3. Agonists used to stimulate platelet activation: COL, Collagen-related peptide; ADP, adenosine diphosphate; TRAP, thrombin receptor activating peptide-6; and AA, arachidonic acid. The bars indicate median and interquartile range.