FIG 3.

Inhibitory effects of azo dyes on the titers of human enteroviruses. (A and B) Titer reduction assays of 8 RD cell-adapted EV71 strains from different subgenogroups (A) and of 4 other clinical isolates of EV71 and 6 coxsackie A viruses (see Table 2) (B) in the presence of E122, E123, E129, or E151. Brackets indicate P values of <0.01 (one-way ANOVA with Dunnett’s posttest in panel A and two-tailed Student’s t test in panel B). (C) Inhibitory effect of E151 on the virus progeny yields of 5 enteroviruses. RD cells were infected with the virus at an MOI of 0.1 in the presence of various concentrations of E151 for 48 h. The titers of the respective virus progeny were determined in RD cells and are presented as percentages of the titer without E151 treatment. The average values ± standard errors of triplicated experiments are shown.