TABLE 1.
Percentages of EV71 variants with different amino acid combinations at VP1-98 and VP1-145a
| EV71 variant | % of variants with indicated no. of sequences from indicated time period |
Total (n = 6,585) | |||||
|---|---|---|---|---|---|---|---|
| To 2007 (n = 607) | 2008–2009 (n = 497) | 2010–2011 (n = 1,481) | 2012–2013 (n = 1,314) | 2014–2015 (n = 1,388) | 2016–2017 (n = 1,298) | ||
| VP1-98E,145E | 64.0 | 68.5 | 81.9 | 88.7 | 88.3 | 84.3 | 82.4 |
| VP1-98K,145E | 10.7 | 15.6 | 6.5 | 6.5 | 6.7 | 9.8 | 8.3 |
| VP1-98E,145G/Q | 24.3 | 15.1 | 10.8 | 4.6 | 4.6 | 5.5 | 8.8 |
| VP1-98K,145G/Q | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Others | 1 | 0.8 | 0.8 | 0.2 | 0.4 | 0.4 | 0.5 |
a
A total of 6,585 EV71 VP1 protein sequences from the NCBI GenBank database were collected and aligned using DNASTAR MegAlign Pro 13.