TABLE 3.
Genetic compartmentalization when sampling HIV sequences from the same site or tissue
| Comparison | Test | Statistic | Result for the following participantc
: |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | |||
| PBMC aliquot A vs aliquot B overall | Distance | KSTa | 0.02 | 0 | 0 | |||||||
| P value | NS | NS | NS | |||||||||
| Tree | No. of migrationsb | 9 | 11 | 13 | ||||||||
| P value | NS | NS | NS | |||||||||
| Right testis location A vs location B overall | Distance | KST | 0.01 | 0 | 0.51 | 0.03 | 0.27− | |||||
| P value | NS | NS | ** | NS | NS | |||||||
| Tree | No. of migrations | 12 | 5 | 1 | 3 | 6 | ||||||
| P value | NS | NS | * | NS | NS | |||||||
| Left testis location A vs location B overall | Distance | KST | 0 | 0.09 | 0 | |||||||
| P value | NS | NS | NS | |||||||||
| Tree | No. of migrations | 17 | 3 | 4 | ||||||||
| P value | NS | NS | NS | |||||||||
a
KST, statistic produced by the Hudson, Boos, and Kaplan nonparametric test for population structure, where 0 indicates no compartmentalization and 1 indicates complete compartmentalization.
b
The number of migrations between compartments required to explain the input phylogeny, as defined by the Slatkin-Maddison test (57). The smaller the number, the stronger the support for compartmentalization.
c
*, 0.01 < P < 0.05; **, P < 0.01; NS, not significant.