FIG 1.

Venn diagram showing total numbers of gene expression changes and overlapping changes in HPV16-positive cervix, foreskin, and tonsil. For microarray analysis of each tissue type, three primary cell lines and three HPV16-transformed cell lines were used to grow rafts. Each of these experiments was repeated at separate times, representing a total of six individually grown raft tissue for primary (n = 6) and HPV16-positive (n = 6) cell lines. Only gene expression changes of more than 1.5-fold and with a P value of <0.05 were considered significant for the analysis.