FIG 2.

Common genes regulated during productive HPV16 infection of cervical, foreskin, and tonsil epithelium. (a) Histograms representing gene expression fold changes of genes commonly regulated. We observe genes belonging to biological functions of the cell cycle, DNA damage repair, and cell division to be upregulated in all the tissues during productive infection. (b to d) Volcano plots representing log₂ fold changes (x axis) plotted against the −log₁₀ P value (y axis), obtained from CLC Genomics Workbench 4.8 package, in HPV16-positive cervical, foreskin, and tonsil rafts. The black scatter points represent all the significantly regulated genes in each tissue type. The commonly regulated genes are color-coded according to their biological functions, as indicated in the key.