TABLE 2.
Comparison of IY7640 and oseltamivir efficacies against group 1 and 2 influenza A viruses as well as influenza B viruses using the CPE assay
|
Virus |
EC50 (μM) |
||||
|---|---|---|---|---|---|
| CPE assay |
Plaque reduction assay, IY7640 | ||||
| Group | Subtype | Strain | IY7640 | Oseltamivir carboxylate | |
| 1 | H1N1 | A/Solomon Island/03/2006 | 0.7 | 206.5 | 0.76 |
| A/Brisbane/59/2007 | 0.62 | 7.11 | 1.53 | ||
| Seasonal/2008a | 3.81 | 964.3 | 1.95 | ||
| pH1N1 | A/Korea/01/2009 (rK09) | 1.95 | 2.17 | 1.58 | |
| A/Netherlands/602/2009 | 2.13 | 2.26 | 2.3 | ||
| A/Korea/2785/2009a | 7.1 | 1323 | 5.11 | ||
| H5N1 | A/chicken/IS/06/2006 (6:2)b | 59.6 | 0.19 | 16.16 | |
| H9N2 | A/chicken/Korea/01310/2001 | 33.39 | 0.63 | 52.23 | |
| 2 | H3N2 | A/Wisconsin/67/2005 | 83.05 | 0.09 | 111.1 |
| A/Brisbane/10/2007 | 110.7 | 493.7 | 1,108 | ||
| A/Perth/16/2009 | 213.9 | 518.4 | 832.4 | ||
| H7N9 | A/Anhui/1/2013 (6:2)b | 221 | 0.81 | 277.1 | |
| B_Victoria | B/Brisbane/60/2008 | 39.68 | 3.25 | 213.7 | |
| B_Yamagata | B/Wisconsin/01/2010 | 17.13 | 0.56 | 47.19 | |
| rg-virusc | pH1N1 | rK09/NA:Y275a | 1.92 | 1,302 | 2.6 |
| rK09/NA:Y275+V222a | 4.79 | 1,991 | 3.73 | ||
a
The NA proteins of these viruses retained the Y275 signature, which promotes resistance to oseltamivir.
b
6:2 viruses were generated on the PR8 backbone.
c
rg-viruses were generated on the K09 backbone.