Figure 6.

Viremia and anti-PRRSV antibodies are not present in CD163 SRCR5-edited animals. (A,B) Blood samples were collected to detect anti-PRRSV antibody titers on days 0, 7, 14, 21, 28, 35, and 42 post PRRSV JXA1 (A) and MY (B) challenge in CD163 SRCR5-edited animals and WT controls. The absorbance was detected at a wavelength of 570 nm. Antibody titers are represented as sample absorbance/positive absorbance (S/P). (C,D) Viral nucleic acid copy numbers in blood samples were measured on the designated days post JXA1 (C) and MY (D) inoculation of CD163 SRCR5-edited and WT animals. The red line represents CD163 SRCR5-edited pigs and the blue line represents WT controls. Data are representative of the results of three independent experiments (means ± SE). Significance is indicated as follows: ^*P < 0.05, ^**P < 0.01, ^***P < 0.001.