. 2017 Dec 15;13(2):142–155. doi: 10.1016/j.jtumed.2017.10.007

Table 1.

Physical characteristics of novel metal complexes of 2-amino-4-substituted phenylthiazole Schiff bases.

Compounds	Chemical name	M. formula	LC-MS (RT, % area)	m/z	R_f	M. P. (°C)	Colour	Yield (%)
4e	5- [(4-Bromo-3-methylphenyl)diazenyl]-2-hydroxybenzaldehyde	C₁₄H₁₁BrN₂O₂	3.053, 95.57	319.01 (M + 1)	0.8	180–90	Dark red (powder)	85
5a(Lig)	4-[(4-bromo-3-methylphenyl)diazenyl)-2-[(4-phenylthiazol-2-ylimino)methyl]phenol	C₂₃H₁₇BrN₄OS	1.581, 99.93	477.3 (M−1)	0.6	235–37	Brown (crystal)	74
5b(Lig)	4-[(4-bromo-3-methylphenyl)diazenyl]-2-[(4-(4-chlorophenyl)thiazol-2- ylimino)methyl]phenol	C₂₃H₁₆BrClN₄OS	1.861, 89.73	512.3 (M + 1)	0.5	242–45	Brown (crystal)	78
6a	Bis[{4-((4-bromo-3-methylphenyl)diazenyl)-2-((4-phenylthiazol-2-limino)methyl)phenoxy}] cobalt	C₄₆H₃₂Br₂CoN₈O₂S₂	1.761, 91.73	1009.3 (M + 1)	0.6	258–60	Brown (powder)	43
6b	Bis[{4-((4-bromo-3-methylphenyl)diazenyl)-2-((4-phenylthiazol-2-ylimino)methyl)phenoxy}] copper,	C₄₆H₃₂Br₂CuN₈O₂S₂	1.351, 97.43	1013 (M + 1)	0.7	262–65	Brown (powder)	49
6c	Bis[{4-((4-bromo-3-methylphenyl)diazenyl)-2-((4-phenylthiazol-2-ylimino)methyl)phenoxy}] nickel	C₄₆H₃₂Br₂N₈NiO₂S₂	1.661, 87.73	1008.79 (M−1)	0.8	253–58	Brown (powder)	51
6d	Bis[4-{(4-bromo-3-methylphenyl)diazenyl}-2-{(4-(4-chlorophenyl)thiazol-2-ylimino)methyl}phenoxy]cobalt	C₄₆H₃₀Br₂Cl₂CoN₈O₂S₂	1.561, 88.73	1079.1 (M + 1)	0.7	238–40	Brown (powder)	53
6e	Bis[4-{(4-bromo-3-methylphenyl)diazenyl}-2-{(4-(4-chlorophenyl)thiazol-2-ylimino)methyl}phenoxy] copper,	C₄₆H₃₀Br₂Cl₂CuN₈O₂S₂	1.356, 81.73	1085.31 (M + 1)	0.8	246–50	Brown (powder)	73
6f	bis[4-{(4-bromo-3-methylphenyl)diazenyl}-2-{(4-(4-chlorophenyl)thiazol-2-ylimino)methyl}phenoxy] nickel	C₄₆H₃₀Br₂Cl₂NiN₈O₂S₂	1.531, 79.73	1081.10 (M + 2)	0.6	253–55	Brown (powder)	67