Table 2.

Summary of ORs and 95%CIs in the association between the IL6 −174 G/C gene polymorphism and the risk of osteoporosis.

No.	Genetic model	Parameter	All	Continent			Gender			Sample size
				Europe	America	Asia	Female	Male	Mixed	S	L
1	G vs C	OR	1.29	1.04	1.90	1.65	1.37	0.90	1.22	1.62	1.07
		95%CI	1.03–1.62	0.93–1.17	1.11–3.23	0.10–26.54	1.00–1.87	0.60–1.37	1.05–1.41	0.87–3.03	1.00–1.15
		p	0.029	0.497	0.019	0.723	0.047	0.635	0.007	0.129	0.094
		pH	<0.001	0.711	<0.001	1.000	<0.001	1.000	<0.001	<0.001	0.296
		pE	0.337	<0.001	0.511	<0.001	0.415	<0.001	<0.001	0.741	0.044
2	GG vs GC + CC	OR	1.20	0.92	1.93	1.65	1.36	0.64	0.78	1.65	0.91
		95%CI	0.84–1.70	0.77–1.09	0.88–4.24	0.10–26.71	0.88–2.10	0.32–1.28	0.63–0.97	0.65–4.18	0.81–1.02
		p	0.313	0.333	0.100	0.722	0.163	0.205	0.024	0.291	0.102
		pH	<0.001	0.722	<0.001	1.000	<0.001	1.000	1.000	<0.001	0.478
		pE	0.517	<0.001	0.768	<0.001	0.588	<0.001	<0.001	1.056	<0.001
3	GC vs GG + CC	OR	1.06	1.26	0.72	1.60	0.89	1.60	2.28	0.82	1.35
		95%CI	0.74–1.50	1.07–1.49	0.37–1.64	0.04–9.75	0.63–1.27	0.89–1.89	1.86–2.80	0.40–1.69	0.94–1.95
		p	0.762	0.005	0.433	0.722	0.535	0.118	<0.001	0.591	0.108
		pH	<0.001	0.627	<0.001	1.000	<0.001	1.000	0.476	<0.001	<0.001
		pE	0.534	<0.001	0.808	<0.001	0.456	<0.001	<0.001	0.855	0.392
4	C vs G	OR	0.77	0.96	0.53	0.60	0.73	1.10	0.82	0.62	0.94
		95%CI	0.62–0.97	0.86–1.08	0.31–1.90	0.04–9.72	0.53–0.10	0.73–1.67	0.70–0.95	0.33–1.15	0.87–1.01
		p	0.029	0.497	0.019	0.723	0.047	0.635	0.007	0.129	0.094
		pH	<0.001	0.711	<0.001	1.000	<0.001	1.000	0.926	<0.001	0.296
		pE	0.337	<0.001	0.511	<0.001	0.415	<0.001	<0.001	0.741	0.044
5	CC vs GG + GC	OR	0.58	0.77	0.31	NA	0.69	0.83	0.32	0.51	0.64
		95%CI	0.39–0.88	0.63–0.95	0.09–1.02	NA	0.49–0.96	0.41–1.67	0.10–1.03	0.29–0.92	0.36–1.14
		p	0.010	0.017	0.054	NA	0.028	0.595	0.056	0.024	0.131
		pH	<0.001	0.589	<0.001	NA	0.003	1.000	0.077	0.051	<0.001
		pE	0.584	<0.001	1.087	NA	0.355	<0.001	0.719	0.512	0.622

Notes OR = odds ratio, CI = confidence interval, p = p value based on a between-study Z test, p_H = p value based on Q test for heterogeneity between studies, p_E = p value based on Egger's test between studies, NA = not available, L = large (≥400 samples), S = small (<400 samples).