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. 2019 Aug 15;15(8):e1008318. doi: 10.1371/journal.pgen.1008318

Fig 7. Pharmacological NOX inhibition phenocopies its genetic ablation and reduces UA related pathologies.

Fig 7

(A) Concretion formation of DaGS>Uro-RNAi #1 or DaGS>Uro-RNAi #2 flies after 14 days of feeding a HY + RU diet supplemented with the indicated concentration of the NOX inhibitor apocynin (ACY). (B, C) Survival curves of DaGS>Uro-RNAi #1 (B) or DaGS>Uro-RNAi #2 (C) flies fed the HY diet without or with 5 mM ACY (+ACY) supplementation in presence or absence of RU. (D) Concretion formation of DaGS>Uro-RNAi #1 flies after 14 days of feeding a HY + RU diet supplemented with the indicated concentration of the ROS scavenger vitamin C (Vit C). (E) As in (B), but 50 mM Vit C (+VitC) supplementation. (F) Key players influencing UA levels and associated pathologies are summarized. See text for more details. Error bars represent the SE of multiple biological repeats.