Figure 3.

Inhibition of HIV-1 Replication in HIV-1-Infected Primary CD4⁺ T Cells

(A and B) HIV-1_NL4-3-infected PBMC-CD4⁺ T cells were treated with indicated FANA ASOs at 400 nM (A) or 3 μM (B). Data represent the relative viral production level calculated based on HIV-1 p24 expression. White circles: DIS-DNA; squares: U5-FANA; triangles: tat/rev-FANA; black circles: DIS-FANA-G9. Asterisks indicate significant differences compared with control (SC-FANA) (**p < 0.01, *p < 0.05, two-tailed Student’s t test). All experiments were performed in triplicate, and data show mean values from at least three assays, each of which used cells isolated from different donors. Error bars indicate SD.