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. 2019 Jul 3;14:246–252. doi: 10.1016/j.omto.2019.06.004

Figure 4.

Figure 4

Treatment with Vaccinia Delta F1L Extends Survival in a Glioblastoma Model and Delays Tumor Growth in a Syngeneic Mouse Colon Model

(A) IVIS imaging of U87 luciferase-expressing tumors seeded intracranially in nude mice after one intracranial injection of either vaccinia or PBS vehicle. (B) Immunohistochemistry (IHC) on slices of U87 tumors treated intracranially with either vaccinia virus and stained with both vaccinia virus antibody and antibody for caspase-3. (C and D) Survival of nude mice seeded intracranially with U87 luciferase-expressing tumors and treated with one intracranial (C) or intravenous (D) dose of 1e7 PFUs of either vaccinia. Survival is shown as Kaplan-Meier survival curves. (E) Colon CT26-LacZ tumors were seeded subcutaneous (subQ) at 5e5 cells in BALB/c mice in a syngeneic model. Two weeks later, mice were treated with one intra-tumoral dose of 1e7 PFUs of either Copenhagen ΔTK or Copenhagen ΔTK/F1L virus. Tumor measurements are displayed. Data is shown as mean and SE. *p < 0.05; ***p < 0.001.