Table 3. Mayo Clinic criteria to diagnose TTC.

LV: left ventricle; CAD: coronary artery disease; ECG: electrocardiography; TTC: Takotsubo cardiomyopathy; ST: ST-segment of ECG; RWMA: regional wall motion akinesia

1	Typical LV contraction pattern: transient hypokinesia, akinesis or dyskinesia in the LV mid-segments with or without apical involvement accompanied with hypercontraction in the basal segments; RWMA that extend beyond a single coronary artery vascular distribution; a stressful trigger is usually but not always present;
2	Absence of obstructive CAD or angiographic evidence of acute plaque rupture;
3	Newly developed ECG abnormalities (ST-segment elevation and/or T-wave inversion) or modest elevation in cardiac troponin;
4	Absence of recent head trauma, intracranial hemorrhage, pheochromocytoma, myocarditis or hypertrophic cardiomyopathy