Table 3.
AEs grade III–IV following neoadjuvant FOLFIRINOX
| Study (reference) | No. | Neutropenia | Leukopenia | Diarrhea | Fatigue | N/V | Thrombocytopenia | Thromboembolism | Weight loss | Febrile neutropenia | Anemia | Abdominal pain | Elevated AST/ALT | Hypoalbuminemia | Neuropathy | Infection | Anorexia | Mucositis |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Paniccia et al. 2014 (25) | 18 | 1 | — | 3 | 2 | 2 | 2 | 1 | — | 1 | 1 | — | — | — | 4 | — | 3 | 1 |
| Christians et al. 2014 (26) | 18 | 2 | — | 2 | — | 5 | — | — | 3 | — | — | 1 | — | — | — | — | 1 | — |
| Katz et al. 2016 (13) | 22 | 3 | — | 3 | — | — | — | 3 | — | — | — | — | — | — | — | — | — | — |
| Okada et al. 2016 (27) | 10 | 4 | 2 | 0 | 1 | 2 | 1 | — | — | 0 | 0 | — | 3 | — | 0 | — | 1 | 0 |
| Yoo et al. 2017 (29) | 18 | 15 | 4 | 1 | 1 | 8 | 0 | — | — | 1 | 0 | 0 | 0 | — | 0 | — | 0 | — |
| Boone et al. 2013 (31) | 25* | 3 | 2 | 1 | — | — | 2 | 1 | 1 | — | — | — | — | 1 | 1 | — | — | — |
| Khushman et al. 2015 (33) | 51* | 10 | — | 5 | 3 | 4 | 8 | — | — | 6 | 5 | — | — | — | — | — | 0 | 0 |
| Blazer et al. 2015 (34) | 43* | 0 | — | 6 | 4 | 2 | 0 | — | — | 0 | 0 | — | — | — | — | — | — | — |
| Grose et al. 2017 (19) | 65* | — | — | 6 | 5 | 3 | — | — | — | 2 | — | — | — | 4 | — | 2 | — | — |
| Tinchon et al. 2013 (37) | 12† | — | — | 1 | — | — | — | 1 | — | — | — | — | — | — | — | — | — | — |
| Peddi et al. 2012 (38) | 61‡ | 12 | — | 2 | 3 | — | 2 | — | 7 | 3 | — | 5 | — | — | — | — | — | — |
| Mahaseth et al. 2013 (39) | 60‡ | 2 | — | 8 | 8 | 5 | 3 | — | — | — | — | — | — | — | 3 | 3 | — | 1 |
| Moorcraft et al. 2014 (40) | 49‡ | 14 | — | 2 | 9 | 3 | 5 | 6 | — | 7 | 2 | — | — | — | 2 | — | — | 2 |
| Stein et al. 2016 (41) | 74‡ | 9 | — | 12 | 9 | 2 | 7 | 3 | — | 3 | 4 | — | 3 | — | 2 | — | — | — |
| Total: 14 | 526‡ | 73 (18)§ | 8 (17)§ | 52 (11)§ | 45 (11)§ | 36 (10)§ | 30 (9)§ | 15 (9)§ | 11 (5)§ | 23 (7)§ | 12 (6)§ | 6 (7)§ | 6 (8)§ | 5 (6)§ | 14 (5)§ | 5 (4)§ | 5 (7)§ | 4 (3)§ |
*
Locally advanced and borderline resectable pooled. AE = adverse event; ALT = alanine transaminase; AST = aspartate transaminase; N/V = nausea and/or vomiting.
†
Metastatic and borderline resectable pooled.
‡
Metastatic, locally advanced, and borderline resectable pooled.
§
Total events per 100 patients.