Table 2.
Characteristics of women tested without an incident breast or ovarian cancer diagnosis, by test year
| Characteristic | Overall | 2005–2008 | 2009–2012 | 2013–2015 | P * |
|---|---|---|---|---|---|
| No. (%) | No. (%) | No. (%) | No. (%) | ||
| Total No. | 991 (100) | 322 (100) | 372 (100) | 297 (100) | |
| Mean age at testing (range), y | 51.7 (18–93) | 52.8 (18–86) | 52.1 (19–84) | 50.2 (19–93) | |
| Age group at testing, y | .11 | ||||
| 18–29 | 45 (4.5) | 12 (3.7) | 12 (3.2) | 21 (7.1) | |
| 30–49 | 338 (34.1) | 100 (31.1) | 130 (35.0) | 108 (36.4) | |
| 50–69 | 539 (54.4) | 183 (56.8) | 204 (54.8) | 152 (51.2) | |
| ≥70 | 69 (7.0) | 27 (8.4) | 26 (7.0) | 16 (5.4) | |
| Race/ethnicity | .03† | ||||
| Hispanic | 58 (5.9) | 13 (4.0) | 23 (6.2) | 22 (7.4) | |
| White | 799 (80.6) | 265 (82.3) | 298 (80.1) | 236 (79.5) | |
| Asian | 47 (4.7) | 12 (3.7) | 16 (4.3) | 19 (6.4) | |
| Black | 37 (3.7) | 11 (3.4) | 15 (4.0) | 11 (3.7) | |
| Other‡ | 33 (3.3) | 9 (2.8) | 16 (4.3) | 8 (2.7) | |
| Missing | 17 (1.7) | 12 (3.7) | 4 (1.1) | 1 (0.3) | |
| Prior breast cancer before age 50 years | 108 (10.9) | 47 (14.6) | 42 (11.3) | 19 (6.4) | .01 |
| FH indicating HBOC risk | |||||
| Yes | 464 (46.8) | 162 (50.3) | 178 (47.9) | 124 (41.8) | .86 |
| No | 294 (29.7) | 106 (32.9) | 107 (28.8) | 81 (27.3) | |
| Missing | 233 (23.5) | 54 (16.8) | 87 (23.4) | 92 (31.0) | |
| Ordering provider | <.001 | ||||
| Oncology | 22 (2.2) | 22 (6.8) | 0 (0.0) | 0 (0.0) | |
| Genetics | 936 (94.5) | 300 (93.2) | 369 (99.2) | 267 (89.9) | |
| Other internal | 4 (0.4) | 0 (0.0) | 3 (0.8) | 1 (0.3) | |
| External | 29 (2.9) | 0 (0.0) | 0 (0.0) | 29 (9.8) | |
| BRCA test type | <.001 | ||||
| Founder mutation panel | 102 (10.3) | 38 (11.8) | 47 (12.6) | 17 (5.7) | |
| Known mutation | 130 (13.1) | 43 (13.4) | 55 (14.8) | 32 (10.8) | |
| Sequencing, c. dup/del | 604 (60.9) | 232 (72.1) | 238 (64.0) | 134 (45.1) | |
| Rearrangement | 46 (4.6) | 8 (2.5) | 31 (8.3) | 7 (2.4) | |
| Sequencing, f. dup/del | 94 (9.5) | 1 (0.3) | 1 (0.3) | 92 (31.0) | |
| Hereditary cancer panel | 15 (1.5) | 0 (0.0) | 0 (0.0) | 15 (5.1) |
*Pvalue for two-sided Pearson χ2test using complete cases unless otherwise noted. c. dup/de l = common duplication/deletion; f. dup/del = full duplication/deletion; FH = family history; HBOC = hereditary breast and ovarian cancer.
†P value for two-sided Fisher exact test using complete cases.
‡Includes individuals who identified as American Indian, Alaskan Native, Native Hawaiian, Pacific Islander, and multiple race or ethnicity categories.