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. 2019 Jan 14;111(8):828–836. doi: 10.1093/jnci/djy215

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© The Author(s) 2019. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — FPR1, TLR3, and TLR4 loss of function (LOF) single nucleotide polymorphisms (SNPs), disease-free survival (DFS), and overall survival (OS) in Short Course in Oncology Therapy (SCOT) cohort. Kaplan Meier curves showing DFS for patients in SCOT cohort by pattern recognition receptor SNPs rs867228 (FPR1 c.1037A>C p.Glu346Ala) (A), rs3775291 (TLR3 c.1234C>T p.Leu412Phe) (B), and rs4986790 (TLR4 c.896A>G, p.Asp299Gly) (C) (LOF allele/amino acid underscored in each case). Corresponding results for OS are shown in D–F. Analyses of the rs4987691 (TLR4 c.1196C>T, p. Thr399Ile) polymorphism, which is strongly linked with rs4986790, were essentially identical to C and F and are provided as Supplementary Figure 1 (available online). Shaded areas represent 95% confidence intervals. P values indicate comparison of all groups by the two-sided log-rank test.