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. 2019 Jan 14;111(8):828–836. doi: 10.1093/jnci/djy215

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© The Author(s) 2019. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — FPR1, TLR3, and TLR4 loss of function (LOF) single nucleotide polymorphisms (SNPs) and overall survival (OS) in COIN/COIN-B cohort. Kaplan Meier curves showing OS for patients in combined COIN/COIN-B cohort by pattern recognition receptor SNPs rs867228 (FPR1 c.1037A>C p.Glu346Ala) (A), rs3775291 (TLR3 c.1234C>T p.Leu412Phe) (B), and rs4986790 (TLR4 c.896A>G, p.Asp299Gly) (C) (LOF allele/amino acid underscored in each case). Analyses of the rs4987691 (TLR4 c.1196C>T, p. Thr399Ile) polymorphism, which is strongly linked with rs4986790, were essentially identical to C and are not shown. Shaded areas represent 95% confidence intervals. P values indicate comparison of all groups by the two-sided log-rank test.