Table 2. Multivariate Logistic Regression Analyses of Factors Associated with Local Recurrence of Giant Cell Tumor of Bone Following Surgery.
| Characteristic | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| OR | 95% CI | p-value | OR | 95% CI | p-value | |
| Age (yr) | 1.05 | 0.98–1.13 | 0.177 | |||
| Sex | 0.862 | |||||
| Male | 1 | |||||
| Female | 0.87 | 0.34–2.11 | ||||
| Duration of symptom (mo) | 0.99 | 0.92–1.06 | 0.849 | |||
| History of trauma | 0.227 | |||||
| No | 1 | |||||
| Yes | 1.87 | 0.67–5.53 | ||||
| Site | 0.003* | 0.113 | ||||
| Distal femur and proximal tibia | 1 | 1 | ||||
| Hand and foot | 3.31 | 2.16–16.74 | 2.96 | 1.13–10.36 | ||
| Others | 0.76 | 0.19–8.47 | 0.69 | 0.13–6.67 | ||
| Size of lesion (cm3) | 1.55 | 0.97–2.47 | 0.061 | |||
| Campanacci grade (plain radiograph) | 0.138 | |||||
| Grade I | 1 | |||||
| Grade II | 2.68 | 0.36–4.36 | ||||
| Grade III | 6.31 | 1.42–11.97 | ||||
| Denosumab used as neoadjuvant | < 0.001* | 0.002* | ||||
| No | 1 | 1 | ||||
| Yes | 3.89 | 1.16–10.14 | 3.12 | 2.48–8.32 | ||
| Pathological fracture | 0.124 | |||||
| No | 1 | |||||
| Yes | 2.38 | 0.63–6.21 | ||||
| Pulmonary metastasis | 0.279 | |||||
| No | 1 | |||||
| Yes | 1.76 | 0.79–3.33 | ||||
| Duration of surgery (min) | 1 | 0.99–1.00 | 0.432 | |||
| Intraoperative blood loss (mL) | 0.99 | 0.95–1.04 | 0.568 | |||
| Use of cement for reconstruction | 0.796 | |||||
| No | 1 | |||||
| Yes | 1.34 | 0.32–4.68 | ||||
| Postoperative complication | 0.133 | |||||
| Yes | 1 | |||||
| No | 1.99 | 0.81–4.88 | ||||
OR: odds ratio, CI: confidence interval.
*Indicates statistical significance.