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Microprojection arrays, a solid microneedle-based device, was used to capture biomarkers in the skin of live mice as reported by Bhargav et al. a-c) The surface of microprojection arrays imaged with SEM. d) Surface modifications with EDC/NHS improved the capturing efficiency. The fluorescence intensities of EDC/NHS-treated MPAs showed an 18-fold increase. Pictures retrieved from Bhargav et al. 2012
