Table 2.
Subjective drug and mood effects at PBO and MA sessions
| Overall (N = 73) | Men (N = 44) | Women (N = 29) | ||||
|---|---|---|---|---|---|---|
| PBO | MA | PBO | MA | PBO | MA | |
| POMS | ||||||
| Friendly | − 1.79 (3.49) | 1.40 (4.74)*# | − 1.20 (2.92) | 0.94 (4.50) | − 2.67 (4.11) | 2.10 (5.09) |
| Anxious | − 0.12 (1.58) | 0.64 (2.86) | − 0.08 (1.64) | 0.84 (2.73) | − 0.19 (1.50) | 0.34 (3.07) |
| Elation | − 1.12 (2.32) | 2.35 (3.63)* | − 0.69 (2.45) | 2.11 (3.42) | − 1.76 (1.98) | 2.71 (3.96) |
| Anger | − 0.29 (1.90) | − 0.36 (1.41) | − 0.46 (2.04) | − 0.14 (1.40) | − 0.67 (1.62) | − 0.71 (1.37) |
| Fatigue | 1.01 (2.70) | − 0.99 (2.39)* | 0.49 (2.76) | − 0.95 (2.27) | 1.81 (2.44) | − 1.05 (2.62) |
| Depression | − 0.38 (1.82) | − 0.51 (2.23) | − 0.41 (2.06) | − 0.16 (1.92) | − 0.33 (1.43) | − 1.05 (2.59) |
| Confusion | 0.40 (2.02) | − 0.14 (2.01) | 0.05 (2.04) | − 0.15 (1.92) | 0.93 (1.89) | − 0.14 (1.85) |
| Vigor | − 2.01 (3.28) | 2.70 (5.25)*# | − 1.43 (3.52) | 1.77 (4.52) | − 2.90 (2.70) | 4.10 (6.00) |
| ARCI | ||||||
| A | − 0.12 (1.33) | 3.30 (2.89)* | 0.02 (1.49) | 3.03 (3.08) | − 0.33 (1.02) | 3.71 (2.56) |
| MBG | − 0.18 (1.74) | 5.27 (4.38)* | − 0.07 (2.11) | 4.94 (4.68) | − 0.36 (0.92) | 5.78 (3.89) |
| LSD | 0.31 (1.35) | 1.05 (1.91)* | 0.33 (1.44) | 1.20 (1.92) | 0.28 (1.25) | 0.83 (1.89) |
| BG | − 1.45 (1.64) | 2.03 (3.00)* | − 1.06 (1.72) | 1.98 (3.06) | − 2.03 (1.34) | 2.12 (2.95) |
| PCAG | 2.41 (2.83) | − 0.08 (3.22)*# | 1.84 (2.99) | 0.25 (3.41) | 3.28 (2.36) | − 0.57 (2.90) |
| M | 0.90 (1.15) | 3.69 (2.16)* | 0.92 (1.21) | 3.63 (2.36) | 0.86 (1.05) | 3.79 (1.83) |
| DEQ | ||||||
| Feel drug | 17.6 (15.7) | 47.2 (23.4)* | 18.9 (17.0) | 46.5 (24.5) | 15.7 (13.8) | 48.2 (20.3) |
| Like effects | 20.3 (21.2) | 62.0 (22.8)* | 24.3 (23.4) | 62.5 (29.2) | 14.2 (15.8) | 61.3 (28.5) |
| Dislike effects | 23.3 (22.7) | 25.4 (21.1) | 23.9 (23.9) | 24.3 (21.9) | 22.6 (21.1) | 27.1 (20.0) |
| Feel high | 10.5 (13.7) | 34.7 (25.0)* | 11.6 (15.7) | 32.7 (25.7) | 8.74 (10.1) | 37.7 (25.7) |
| Want more | 16.6 (21.4) | 58.8 (30.7)* | 20.0 (24.1) | 60.9 (31.6) | 11.5 (15.5) | 55.6 (29.6) |
| Cardiovascular | ||||||
| Heart rate | − 7.87 (9.84) | 4.49 (12.1)* | − 8.44 (7.58) | 3.45 (11.7) | − 7.03 (12.5) | 6.02 (12.6) |
| Blood pressure | − 4.14 (7.04) | 11.2 (10.1)* | − 5.48 (5.44) | 9.65 (11.4) | − 2.06 (8.69) | 13.7 (7.11) |
Values represent peak change scores from baseline at each session ± standard deviation. POMS, Profile of Mood States; ARCI, Addiction Research Center Inventory; A, amphetamine scale; MGB, morphine-Benzedrine group scale; LSD, lysergic acid diethylamide scale; BG, Benzedrine group scale; PCAG, pentobarbital, chlorpromazine, and alcohol group scale; M, marijuana scale; DEQ, Drug Effects Questionnaire. Blood pressure calculated as mean arterial pressure ((systolic BP + 2 × diastolic BP) ∕ 3). *p < 0.05, effect of drug; #p < 0.05, drug × gender interaction. Bold values are significant at corrected p < 0.05; italicized values are significant at uncorrected p < 0.05